pinoygasil.blogg.se - Study stack pharmacology

STUDY STACK PHARMACOLOGY FULL

Study of the action of drugs on living tissues (mechanism of action) Pharmacodynamics, pharmacokinetics, pharmacotherapeutics, pharmacy, posology, toxicology The study of drugs and their interactions with living organisms. To see how well you know the information, try the Quiz or Test activity.Pharmacology: U1 Unit 1 terms/data Question When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug.Īlthough it may feel like you're playing a game, your brain is still making more connections with the information to help you out. If you are logged in to your account, this website will remember which cards you know and don't know so that theyĪre in the same box the next time you log in.

LEFT ARROW - move card to the Don't know pile.

You can also use your keyboard to move the cards as follows: If you've accidentally put the card in the wrong box, just click on the card to take it out of the box. When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again. If you knew the answer, click the green Know box. Look at the large card and try to recall what is on the other side. Use these flashcards to help memorize information. LD50:ED50 - measure of a drug's safety - the higher the therapeutic index, the safer the drug Subsequent doses must be "fine tuned" based on patient's response. The initial dose is just an approximation. Interpatient Variability in Drug Responses The dose required to produce a defined therapeutic response in 50% of the population (Average effective dose) Simple physical or chemical interactions with other small molecules - examples of receptorless drugs: antacids, antiseptics, saline laxitives, chelating agents Continuouse exposure to antagonists can -> hypersensitivity.ĭrug Responses That Do Not Involve Receptors

STUDY STACK PHARMACOLOGY FULL

Have only moderate intrinsic activity - maximal effect can produce less than that of a full agonist - can act as antagonists as wellĬontinuouse exposure to agonists can -> receptor desensitization (downregulation).

Molecules that activate receptors - have both high affinity & high intrinsic activity - can make processes go faster or slowerĭrugs that prevent receptor activation - have affinity, but no intrinsic activity - have virtually no effects of their own on receptor functionīind irreversibly - impact not permanent (until cell dies & replaced by new one)Ĭompete with agonists for receptor binding - reversible - equal affinity (whichever has highest concentration) Strength of the attraction of the drug to its receptor (reflected in its potency)Ībility of the drug to activate a receptor upon binding - drugs with high intrinsic activity cause intense receptor activation (have high maximal efficacy) Incorporates affinity & intrinsic activity into the equation Intensity of response to a drug is proportional to the number of receptors occupied If a drug interacts with only one type of receptor, & if that receptor type regulates just a few processes, then the effects of the drug will be relatively selective - the more selective a drug, the fewer SE's it will have Immediate response - R + GTP + Effector - serpentine structure that spans cell membrane 7 timesĭelayed response - located on DNA in cell nucleus - stimulate transcription of mRNA to make protein - only activated by lipid soluble ligands Immediate response - receptor spans membrane - binding of drug opens channel so specific ions can go through (direction depends on ) Immediate response - receptor spans membrane - binding of drug causes increased catalytic activity on other side of membrane The amount of drug we must give to elicit an effect - a potent drug produces its effects at low doses (potency isn't that important)Ĭhemicals that produce effects by interacting with other chemicals - drugs cannot give cells new functionsĪny functional macromolecule in a cell to which a drug binds to produce its effectsĢ) Receptor activity regulated by endogenous compoundsģ) Drug binding either mimics or blocks action of endogenous molecules (doesn't create new actions) The largest effect that a drug can produce - match the intensity of the response with the patient's need (e.g. Relationship between the size of an administered dose & the intensity of the response produced - usually graded (gets more intense with higher dose)ģ) How much we need to increase the dosage to produce the desired increase in response The study of the biochemical & physiologic effects of drugs & the molecular mechanisms by which those effects are produced (what drugs do to the body & how they do it)